RESPIRATORY FAILURE IN ACUTE ORGANOPHOSPHATE POISONING: MECHANISMS, RECOGNITION, AND MANAGEMENT

Sat, 14 Feb 2026 00:00:00 +0000

Organophosphate (OP) poisoning is one of the serious health problems globally, especially in the agricultural regions of low, and middle, income countries, and respiratory failure has been identified as the principal cause of death. This review to summarize the main features of pathophysiology, diagnosis, and treatment of respiratory failure caused by OP poisoning. Respiratory failure is the result of the conjunction of multiple mechanisms, such as muscarinic, neuromuscular junction, and central depression. The clinical manifestations can be ranging from acute cholinergic crisis to intermediate syndrome so that the patient has to be carefully monitored and treated as soon as possible. The therapeutic approach involves immediate airway control, use of mechanical ventilation, and administration of atropine and oximes, which are antidotes. Although the pathophysiology of the disease has been well elucidated, the death rate is still high, so it is critical to make an early diagnosis and to administer intensive treatment without delay. This article presents a management protocol for this life-threatening condition currently supported by the existing scientific literature.

International Journal of Trends in OncoScience

RESPIRATORY FAILURE IN ACUTE ORGANOPHOSPHATE POISONING: MECHANISMS, RECOGNITION, AND MANAGEMENT